94th Canadian Chemistry Conference and Exhibition


Biological and Medicinal Chemistry

Monday AM

BM7511e

Altered Proteins, Design and Engineering

Organizer(s) - J. Pelletier; R. Chica
Chair(s) - Nicolas Doucet

Joint with PT7 - Computational Biochemistry and Drug Design

08:00 00199 A Rigorous and Straightforward Boundary Potential for QM/MM Simulations of Ion Solvation Rowley C.N., *$Roux B.
08:20 00200 3-Hydroxyanthranilic Acid Analogues as Amyloid-Beta Antiaggregants: The Development of a Quantitative Structure-Activity Relationship $Simms G.A., Meek A., *Weaver D.F.
08:40 00201 Compared Distributions of Amino Acid Hetero- and Homo-multiplets in Single Protein Chains: Dependence on Residue Polarity, Frequency, and Placement in Secondary Structural Elements Gong C., *$Arteca G.A.
09:00 00202 Computer Modeling of Zinc-binding Motifs in Proteins *$Lamoureux G., Wang S.
09:20 00203 The Selective Tuning of Fc-FccR Interactions for Modulating ADCC: A Structure Guided Approach to Antibody Optimization D'Angelo I., Bleile D., Tom-Yew S.A.L., Lario P.I., Ohrn A., Poon D.K.Y., *$Dixit S.B.
10:00 Coffee Break
10:20 00204 Recent Advances in Computational Protein Design with an Emphasis on Catalytic Systems Mayo S.L.
11:00 00205 In Silico Screening of Computational Enzyme Designs Sosa Padilla Araujo B., Miller III T.F., *$Mayo S.L.
11:20 02414 The Role of Evolutionary-conserved Ligand-interacting Binding Site Residues Najmanovich R.
12:00 00207 Library Design and Multistate Design: Powerful Computational Strategies for Protein Engineering *$Chica R.A.
12:20 End of Session

BM5512c

Biopolymers and Other Biomaterials for Medical Applications (joint with MT3)

Organizer(s) - F. Winnick; E. Gillies
Chair(s) - Francoise Winnik

08:00 00208 Non Phospholipid Liposomes with High Sterol Content: Development and Characterization *Cui Z.-K., $Lafleur M.
08:20 00209 High-throughput Microfluidic Generation of Cell-Laden Agarose Microgels *Tumarkin E., Tzadu L., Zandstra P., $Kumacheva E.
08:40 00210 Use of Model Systems for Targeted Nanoparticle Studies Viitala T., Liang H., Yliperttula M.
09:20 00211 Self-immolative Polymers: A New Class of Biodegradable Materials DeWit M.A., Beaton A., *$Gillies E.R.
09:40 00212 Spectral Overview of Some New Antimicrobial Polyureas and its Metal Polychelates: Their Synthesis and Adsorption Properties *Hasnain S., Nishat N.
10:00 Coffee Break
10:20 00213 Micropipette Aspiration of Alginate based Poly-electrolyte Capsules Kleinberger R.M., Burke N.A.D., *$Stover H.D.H
10:40 00214 Study of Crosslinking Chemistry and Polymer Distribution in Covalently Crosslinked Polymer- Alginate Capsules Mohajeri S., Burke N.A.D., *Stover H.D.H.
11:00 00215 Macromolecular Design in Constructing Smart Nanocarriers for Biomedical Applications *$Kakkar A.K.
11:40 00216 188Re-radiolabelled Monosized Biodegradable Microspheres for the Treatment of Liver Cancer *Saatchi K., Elischer P., Bokharaei M., Celler A., Liu D., $Hafeli U.O.
12:00 00217 Polymeric Reagents for CyTOF Cell Analyzer Instrument *Lou X., Ornatsky O., Baranov V., Winnik M.A. WITHDRAWN
12:20 End of Session

BM15515a

Metabolic Disorders

Organizer(s) - C. Black
Chair(s) - Cameron Black

08:40 00218 The Discovery of Melanin-Concentrating Hormone Receptor-1 (MCH1) Antagonists for the Treatment of Obesity Surman M.
09:20 00219 Liver-Targeted Stearoyl Coenzyme-A Desaturase Inhibitors for the Treatment of Diabetes *Ramtohul Y., Bateman K., Black C., Chan C., Dohlman S., Gordon R., Guay J., Huang Z., Hughes G., Isabel E., Kennedy B., Lachance N., Landry F., Leblanc Y., Leclerc J.-P., Leger S., Li C.S., Mancini J., Oballa R., Powell D., Skorey K.
10:00 Coffee Break
10:20 00220 Function of Enzyme Lactate Dehydrogenas in Relation with Lipid and Glucose in Biotic and Abiotic Stresses in the Seedlings of Vigna radiata *$Azmat R.
10:40 00221 Small Molecule Inhibitors of 11-bHSD1 Containing Acidic Functionality: The Discovery of AZD6925 Scott J.S.
11:20 00222 The Discovery and Characterization of Orally Bioavailable Inhibitors of PTP-1B Black W.C.
12:00 00223 How Would pi-stacking Affect the Formation of Salt Bridge? Binding study and Molecular Dynamic Simulation of pi-stacked Arginene Motif Wang X., *Hore D., $Hof F.
12:20 End of Session

BM8510a

Nucleic Acids Chemistry and Biology (joint with OR11)

Organizer(s) - M.J. Damha; C.J. Wilds
Chair(s) - Masad Damha

08:00 00224 Structural Impact of C8-Aryl-Gaunine Adducts on Duplex DNA *$Manderville R.A.
08:20 00225 Interaction of O6-Alkylguanine DNA Alkyltransferases with O4-Alkylthymine Adducts and Interstrand Cross-Linked DNA McManus F.P., O'Flaherty D.K., Noronha A.M., *$Wilds C.J.
08:40 00226 Platinum(II) Phenanthroimidazoles for G-quadruplex Targeting: The Effect of Structure on Binding Affinity, Selectivity and Telomerase Inhibition Castor K.J., Kieltyka R., Englebienne P., Weill N., Fakhoury J., Mancini J., Avakyan N., Mittermaier A., Autexier C., Moitessier N., $Sleiman H.F.
09:00 00227 Ferrocene-ATP Bioconjugates: Chemical Biology and Biosensing Toolkit *Martic S., Freeman D., Labib M., $Kraatz H.B.
09:20 00228 Effects of Helix Distortion on DNA Interstrand Cross-link Repair In Mammalian Cells Smeaton M.B., Bell E.H., Miller P.S.
10:00 Coffee Break
10:20 00229 Using Tetraplex DNA as a Structural Template *$Linkletter B.A.
10:40 00230 Towards Oligonucleotides Containing DNA-Inspired Janus AT Heterocycles Hasan S.A., *$Perrin D.M.
11:00 00231 An Indole-Linked C8-Deoxyguanosine Nucleoside Acts as a Fluorescent Reporter of Watson-Crick Versus Hoogsteen Base Pairing Schlitt K.M., *$Manderville R.A., Millen A.L., Wetmore S.D.
11:20 00232 Mechanistic Studies at the Single Molecule Level Reveal the Dynamics of HCV Polymerase Protein in Complex with RNA Karam P., Mah W., Powdrill M., Vasquez C., Aboukhalil R., Gotte M., $Cosa G.
11:40 00233 The Effect of Synthetic Vertices and DNA-Vertex Connectivity on the Stability of Self-Assembled DNA Nanostructures Greschner A., $Sleiman H.
12:00 End of Session

BM2511a

Peptide Science (joint with OR6)

Organizer(s) - W. Lubell; F. Polyak
Chair(s) - William Lubell

08:00 00234 Molecular Probes for Imaging and Isolation-Identification of Newly Synthesized Proteins in Cells Szychowski J., Mahdavi A., Beatty K.E., $Tirrell D.A.
08:20 00235 Bis-Azobenzenes for Photo-Controlling Structures and Functions of Peptides and Proteins Samanta S., $Woolley A.
08:40 00236 Rational and Nonrational Design of Transcription Factors Shin J.A.
09:00 00237 Structural Optimization and Biological Evaluation of Radiolabelled Peptides as Diagnostic Tools for PET Imaging *$Guérin B.
09:40 00238 Peptidic Fluorescent Probes of Transglutaminase 2 Mulani A., Chabot N., Moreau S., Moreau P., Keillor J.W.
10:00 Coffee Break
10:20 00239 Conformation-induced Binding of Extracellular Loops of the Apelin Receptor with the Apelin Ligand in Lipid Environments Ngweniform P., *$Rainey J.K.
10:40 00240 Engineering Proteolytically Stable Breast Cancer Targeting Peptides *$Kaur K.
11:20 00241 Methylated Lysines as Unique Sites for Small-molecule Recognition and Biomedical Interventions *$Hof F., Daze K., Minaker S., Pinter T.
11:40 00242 Cycloinformatics *$Yudin A.K.
12:20 End of Session


Monday PM

BM7513e

Altered Proteins, Design and Engineering

Organizer(s) - J. Pelletier; R. Chica
Chair(s) - Roberto Chica

13:40 00243 Characterization of a New Photoactive Yellow Protein Kane L., $Woolley G.A.
14:00 00244 Cellobiohydrolase Substrate Specificity Switch *Montalibet J., Arzhangi Z., Lavigne J., Mather R., St-Pierre P., Tremblay A., $Tomashek J.
14:20 00245 Substrate and Reaction Specificity in the Enzymes of the Transsulfuration Pathways *$Aitken S.M., Lodha P.H., Jaworski A.F., Manders A.L., Hopwood E.M.S.
14:40 00246 Chimeric TEM-1/PSE-4 b-lactamases: Kinetic and Structural Properties of Artificially-evolved Enzymes Gobeil S., Clouthier C.M., Nguyen E., $Pelletier J.N.
15:00 00247 Engineering Synthetic Control Over Rho GTPases Using Calcium and Calmodulin Signaling Mills E., *$Truong K.
15:40 Coffee Break
16:00 00248 Engineering a Transaminase for Sitagliptin Manufacture *Savile C.K., Janey J.M., Mundorff E.C., Moore J.C., Tam S., Jarvis W.R., Colbeck J.C., Krebber A., Fleitz F.J., Brands J, Devine P.N., Huisman G.W., Hughes G.J.
16:40 00249 FRep: A Fluorescent Protein-based Bioprobe for In Vivo Detection of Protein:DNA Interactions Shin J.A.
17:00 00250 Dissecting the Energetics of the Folding and pH-Myristoyl Switch of Hisactophilin Smith M.T.J., *$Meiering E.M.
17:20 00251 Designing Miniature Titin-like Proteins for Construction of Muscle-Mimetic Biomaterials *$Li H., Lv S., Cao Y., Balamurali B., Dudek D., Gosline J.
18:00 End of Session

BM5512c

Biopolymers and Other Biomaterials for Medical Applications (joint with MT3)

Organizer(s) - F. Winnick; E. Gillies
Chair(s) - Patrick Hildgen

13:40 00252 Natural and Transgenic Spider Silk Proteins Investigated by NMR Leclerc J., Larouche J., Verreault-Lapointe C., Morency L.P., Lefèvre T., Pézolet M., Gagné S.M., *$Auger M.
14:00 00253 Development of Biocompatible Nanocomposites for Local Delivery of Growth Factor *$Zhang J, Kim H.L.
14:20 00254 Glycopolymers and Glyconanoparticles for Gene Delivery *$Narain R., Ahmed M.
15:00 00255 Towards Enhanced Gadolinium Contrast Agents for MRI: A Comparison of Macromolecular Architectures Homenick C.M., Atkins K., Mackey V., Maris M., Soleimani R., Martinez F., Scholl T., $Gillies E.R.
15:20 00256 Effect of PEG-Grafted Phospholipid Lateral Distribution on the Phase Behavior of Zwitterionic Phospholipid Membranes Tanwir K., Shahid M.N., Nosrati N., Bhayani T., Thomas A., *$Tsoukanova V.
15:40 Coffee Break
16:00 00257 A Novel Combinatorial Method for Polyelectrolyte Multilayer Fabrication Sailer M., $Barrett C.J.
16:20 00258 Pegylated Bile Acids Used as Pharmaceutical Agents for Enhanced Drug Solubilization : Biocompatibility and Application Le Dévédec F., *Zhu X.X.
16:40 00259 Water-soluble Azlactone based Reactive Polymers for Biomedical Applications *Gardner C.M., $Stöver H.D.H.
17:00 00260 Assembly of Three-Dimensional DNA Super-Structures Conway J.W., McLaughlin C.K., Hamblin G., *$Sleiman H.
17:20 00261 Smart Lipid-and Polymer-Based Substrates for Artificial Synapses *Gopalakrishanan G., Yam P.T., Thostrup P., Lucido A.L., Rouiller I., Colman D.R., $Lennox R.B.
17:40 00262 Development of Films Made of Proteins Extracted from the Anchoring Threads of Marine Mussels Byette F., Marcotte I., *$Pellerin C.
18:00 End of Session

BM8510a

Nucleic Acids Chemistry and Biology (joint with OR11)

Organizer(s) - M.J. Damha; C.J. Wilds
Chair(s) - Chris Wilds

13:40 00263 Gene-silencing, Stability and Structural Properties of Fluorine Modified Nucleic Acids *$Egli M.
14:20 00264 18F-Aryltrifluoroborate Labeled Oligonucleotide Via Click Chemistry Li Y., *$Perrin D.M.
14:40 00265 Evidence for C-HàF-C Pseudohydrogen Bonding in 2'F Modified Nucleic Acid Duplexes Yahyaee Anzahaee M., Watts J.K., Martin-Pintado N., Gomez-Pinto I., Gonzalez C., *$Damha M.J.
15:00 00266 Recognition and Maturation of Effector RNAs in a CRISPR Interference Pathway *$MacMillan A.M.
15:20 00267 Effect of Several Fluorine Substitutions in DNA and RNA Structures *Martin-Pintado N., Deleavey G., Watts J., González C., $Damha M.J.
15:40 Coffee Break
16:00 00268 BODIPY in Oligonucleotide Lablelling *$Yan H., Yang L., Tram K., Wang Q.
16:20 00269 2'F-ANA-Modified AONs and siRNAs: Biological Applications, Structural Considerations, and Delivery Strategies Deleavey G.F., Watts J.K., Robert F., Martin-Pintado N., Soifer H., Chan D., Le P., Petrecca K., Shoichet M., Stein C., Pelletier J., *$Damha M.J.
16:40 00270 Single Molecule Fluorescence Characterization of DNA Based Nano-architectures Hariri A., Karan P., Lo P., Hamblin G., *Sleiman H., $Cosa G.
17:00 00271 Synthesis of High-Density RNA Microarrays Somoza M.M., Lackey J.G., Johnson R., Mitra D., Koh Y., Wickens M., Damha M.J.
17:20 00272 Integral Modification to Nucleic Acids and Analogues via "Click" Chemistry *$Hudson R.H.E.
17:40 End of Session

BM2511a

Peptide Science (joint with OR6)

Organizer(s) - W. Lubell; F. Polyak
Chair(s) - David Sabatino

14:20 00273 Self-Assembled Synthetic Ion Channels Yang D.
15:00 00274 Porphyrin Decorated Peptide Sequences for LIght-Harvesting Applications Akerfeldt K.S., Johnson W., Robilotti B.W., Kokona B.
15:40 Coffee Break
16:00 00275 Tuning the Receptor Selectivity of GHRP-6 by Exploiting the Reactivity of Semicarbazones and Aza-Propargyl Glycine in Combinatorial Azapeptide Synthesis Proulx C., Sabatino D., Pohankova P., Ong H., *$Lubell W.D.
16:20 00276 Preclinical Characterization of a Nerve Growth Factor Peptidomimetic for the Treatment of Dry Eye Disease *$Meerovitch K., Lama T., Cumberlidge G., Saragovi H.U.
17:00 00277 Development of Substance P Related Small Peptides and Peptidomimetics with Intriguing Effects on Neuropathic Pain Sandström A.
17:40 00274 Design of a Library to Explore the Amatoxin and Phallotoxin Chemical Space Blanc A., $Perrin D.M.
18:00 End of Session


Tuesday AM

BM7513e

Altered Proteins, Design and Engineering

Organizer(s) - J. Pelletier; R. Chica
Chair(s) - Joelle Pelletier

08:40 00278 Employing Multi-modal Imaging to Monitor HCV Core Protein's Dynamic Involvement on Host Lipid Droplet Kinetics *Lyn R.K., Kennedy D.C., Pegoraro A.F., Ridsdale A., Stolow A., McLauchlan J., $Pezacki J.P.
09:00 00279 Can Enzyme Engineering Benefit from the Modulation of Protein Motions? Lessons Learned from RNase A Doucet N., $Loria J.P.
09:20 00280 Designing Photo-controlled Transcription Factors Woolley A.
10:00 Coffee Break
10:20 00281 Exploring the Structure, Function, and Dynamic Properties of Class-A b-lactamases Clouthier C.M., Morin S., Gobeil S., Gagne S., *$Pelletier J.N.
10:40 00282 Protein Engineering of Ice-binding Proteins *$Davies P.L., Celik Y., Pertaya N., Braslavsky I.
11:20 End of Session

BM5512c

Biopolymers and Other Biomaterials for Medical Applications (joint with MT3)

Organizer(s) - F. Winnick; E. Gillies
Chair(s) - Ravin Narain

08:00 00283 Microbial Medium Chainlength Poly[(R)-3-hydroxyalkanoate] Shows Liquid Crystal Behaviour *$Marchessault R.H., Dou H., Ramsay J.
08:20 00284 Photoresponsive Silicones for Ophthalmic Drug Delivery Fawcett A.S., *Brook M.A.
08:40 00285 Reactive Polymers for Cell Encapsulations Stöver H.
09:20 00286 Stabilization of Perfluorocarbon Ultrasound Contrast Agents by Polyelectrolyte Deposition Martin A.L., Seo M., Gorelikov I., $Matsuura N.
09:40 00287 Linear Diblock Copolymers of L-Lactide and 2-Dimethylaminoethyl Methacrylate: Synthesis, Thermal and Crystallization Studies *$Kryuchkov M.A., Detrembleur Ch., Jérôme R., Prud'homme R.E., Bazuin C.G.
10:00 Coffee Break
10:20 00288 Preventing the Formation of Biofilms Using Phage-functionalized Surfaces Hosseinidoust Z., van de Ven T.G.M., *$Tufenkji N.
10:40 00289 Self-assembled Thin Films of Biopolymers/Magnetic Nanoparticles for Biomedical Applications *$Ahmad N., Hassan M., Saqib M., Faraz A.
11:00 00290 Controllable Bio-fabrication and Functionalization of Bacterial Cellulose Yang G., Shi X., Fu L., Shi Z., Liu K., Sun Z.
11:20 End of Session

BM8510a

Nucleic Acids Chemistry and Biology (joint with OR11)

Organizer(s) - M.J. Damha; C.J. Wilds
Chair(s) - Chris Wilds; Masad Damha

08:20 00291 Structural Dynamics and Editing of Non-Coding RNA: Links to Primate Evolution Dahabieh M.S., *$O'Neill M.A.
08:40 00292 Lanthanum-catalyzed Biomimetic Protecting-group-free Aminoacylation of RNA Derivatives Her S., *$Kluger R.
09:00 00293 Development of a Novel Solid Support Linker for Oligonucleotide Synthesis Johnsson R., Lackey J.G., $Damha M.J.
09:20 00294 Synthesis and Characterization of Novel siRNA Prodrugs for Effective Delivery Bogojeski J., Johnsson R., Lackey J., $Damha M.
09:40 00295 Replacing the Backbone of siRNAs with Unnatural Heterocycles Efthymiou T.C., Fischer J., Huynh V., Gong W., *$Desaulniers J.P.
10:00 Coffee Break
10:20 00296 New Advances in The Synthesis of Oligoribonucleotides Hassler M.R., *Reddy N.M.K., Chan T.-H., $Damha M.J.
10:40 00297 A Rapid and General Procedure for the Synthesis of Dinucleoside Polyphosphates Mohamady S., *Taylor S.
11:00 00298 Modifying Nucleic Acid Building Blocks for Investigating Structure and Function in Oligonucleotides *$Sabatino D.
11:20 End of Session

BM2511a

Peptide Science (joint with OR6)

Organizer(s) - W. Lubell; F. Polyak
Chair(s) - Felix Polyak

08:20 00299 Synthesis of Sulfotyrosine Peptides Using a Sulfate Protecting Group Strategy *$Taylor S.D., Ali A.M.
08:40 00300 Biomimetic Peptide Bond Formation in Water Dhiman R., *Guevara Opinska L., $Kluger R.
09:00 00301 Branched Peptide Ligation Assem N., $Yudin A.K.
09:20 00302 Submonomer Solid-Phase Synthesis of Bio-Active Peptidomimetics *$Sabatino D.
09:40 00303 From Diverse Phage Libraries of Peptides to Design of Biomaterials and Forward Chemical Genetics *$Derda R., Ns S., Jafari M.R., Matochko W., Kiessling L.L., Whitesides G.M.
10:00 Coffee Break
10:20 00304 Structure, Formation and Activity of Sulfur-Containing Peptides *$Vederas J.C.
11:00 00305 Targeting the Prostaglandin F2a Receptor for Developing Treatments Against Preterm Labor Bourguet C.B., Goupil E., Tassy D., Hou X., Thouin E., Polyak F., Hébert S., Claing A., Laporte S., Chemtob S., *$Lubell W.D.
11:20 End of Session

BM4517d

Advances in Spectroscopy and Imaging for Biological Systems (joint with PT4)

Organizer(s) - R. Campbell; G. Cosa
Chair(s) - Robert Campbell

08:00 See PT4.

11:00 End of Session

BM6511b

Carbohydrates and Glycobiology (joint with OR7)

Organizer(s) - S. Sato; T. Lowary; D. Jakeman
Chair(s) - Sachiko Sato

08:00 00306 Structural and Mechanistic Characterization of Leukocyte Type Core 2 b1,6-N-Acetylglucosaminyltransferase: A Metal-Ion Independent GT-A Glycosyltransferase *$Rini J.M., Pak J.E., Satkunarajah M., Seetharaman J.
08:40 00307 Biocompatible Copper(I) Catalysts for In Vivo Imaging of Glycans Soriano del Amo D., Marlow F.L., *$Wu P.
09:00 00308 The Influence of Stereochemistry on the Ice Recrystallization Inhibition (IRI) Activity of Mono-, Di- and Trisaccharide Derivatives Capicciotti C.J., Gouliaras C., Taylor M.S., *$Ben R.N.
09:20 00309 Use of N,Odimethylhydroxylamine as an Anomeric Protecting Group in Carbohydrate Synthesis Dasgupta S., *$Nitz M.
09:40 00310 Towards Drug Candidates Against Influenza A *$Pinto B.M.
10:00 Coffee Break
10:20 00311 Synthesis of Glycolipid Analogues Towards the Design of Biomimetic Cell Membranes Singh S., $Auzanneau F.-I.
10:40 00312 A Systems Biology Approach to Understand Protein N-Glycosylation Dennis J.W.
11:20 End of Session

BM13513d

Natural Product Chemistry (joint with OR4)

Organizer(s) - C. Spino
Chair(s) - Bruno Ndzi

08:00 See OR4.

11:20 End of Session


Tuesday PM

BM8510a

Nucleic Acids Chemistry and Biology (joint with OR11)

Organizer(s) - M.J. Damha; C.J. Wilds
Chair(s) - Yingfu Li; Dipankar Sen

13:40 00313 Engineering and Application of Fluorogenic DNAzymes *$Li Y.
14:00 00314 Tuning a DNAzyme's Antenna: Moving Towards Visible Light Barlev A., *Sekhon G., $Sen D.
14:20 00315 Fluorescent Signaling DNAzymes for Sensing Bacteria Ali M., Aguirre S.D., *$Li Y.
14:40 00316 A Fast Radical-trap Investigation of the Mechanism of a DNAzyme with Photolyase Activity *Sekhon G.S., $Sen D.
15:00 00317 Thermodynamics of Steroid Binding by a Modifed Cocaine-binding Aptamer Reinstein O., *Neves M.A.D, Saad M., $Johnson P.E.
15:20 00318 Guanine-rich RNAs and DNAs that Bind Heme Robustly Catalyze Oxygen Transfer Reactions Poon L., Methot S, Morabi-Pazooki W., Pio F., Bennet A., Shumayrikh N., *$Sen D.
15:40 Coffee Break
16:00 00319 DNA Aptamers for Imaging and In Vivo Applications *DeRosa M.C.
16:20 00320 In Vitro Selection of Thiamin-Assisted RNA Catalysts *Cernak P., $Sen D.
16:40 00321 Detection of Mycotoxins Using Aptamers McKeague M., Meszaros T., Visconti A., DeGirolamo A., Miller J.D., *$DeRosa M.C.
17:00 00322 Adenosine-induced Elimination of Redox Intercalators in a DNA Conformational Switch Dai Y., Chakraborty B., *Yu H.-Z.
17:20 00323 Development of Intelligent Ribozymes *$Perreault J.P.
17:40 End of Session

BM4517d

Advances in Spectroscopy and Imaging for Biological Systems (joint with PT4)

Organizer(s) - R. Campbell; G. Cosa
Chair(s) - Chris Yip

13:40 See PT4.

17:40 End of Session

BM6511b

Carbohydrates and Glycobiology (joint with OR7)

Organizer(s) - S. Sato; T. Lowary; D. Jakeman
Chair(s) - Todd Lowary

R.U. Lemieux Award Lecture

13:40 00324 Towards Efficient Synthesis of Glycoconjugates Through Engineering and Evolution of Glycosyl Transferases and Glycosynthases *$Withers S.G.
14:20 00325 Organoboron Catalyzed Regioselective Glycosylations Gouliaras C., Lee D., *Chan L., $Taylor M.S.
14:40 00326 Development of More Efficient Screening Methods for Boroxole-based Libraries of Carbohydrate Receptors Lu J.-Y., Pal A., *$Hall D.G.
15:00 00327 Structural Analysis of Pneumococcal Carbohydrate-degrading Virulence Factors Reveals Insights into Carbohydrate Recognition *$Boraston A.B.
15:40 Coffee Break
16:00 00328 Beyond Metal and Azide Mediated Click Reactions: Applications to Glycoscience *$Boons G.J.
16:40 00329 A Novel Strategy for Obtaining Orthogonally Protected Idopyranosyl Building Blocks *Hevey R., $Ling C.-C.
17:00 00330 Synthesis, Characterization, and Enzyme Analysis of Ketose-Phosphonate Analogues Forget S.M., *$Jakeman D.L.
17:20 00331 5'-Methylthioadenosine Nucleosidase Plays a Key Role in the Modified Futalosine Pathway for Menaquinone Biosynthesis Li X., Apel D., Gaynor E.C., *Tanner M.E.
18:00 End of Session

BM13513d

Natural Product Chemistry (joint with OR4)

Organizer(s) - C. Spino
Chair(s) - Guillaume Belanger

13:40 See OR4.

18:00 End of Session

BM12513e

Computational Biochemistry and Drug Design (joint with PT7)

Organizer(s) - G. Lamoureux; N. Moitessier
Chair(s) - Nicolas Moitessier

13:40 See PT7.

18:00 End of Session

BM17516d

Solution NMR: Biomolecular Structure, Dynamics, and Function (joint with PT9)

Organizer(s) - A. Mittermaier; P. Lavigne
Chair(s) - Anthony Mittermaier

13:40 See PT9.

18:00 End of Session


Wednesday AM

BM4516e

Advances in Spectroscopy and Imaging for Biological Systems (joint with PT4)

Organizer(s) - R. Campbell; G. Cosa
Chair(s) - Gonzalo Cosa

08:00 See PT4.

12:20 End of Session

BM6511b

Carbohydrates and Glycobiology (joint with OR7)

Organizer(s) - S. Sato; T. Lowary; D. Jakeman
Chair(s) - David Jakeman

08:00 00332 Towards the Development of High Affinity Inhibitors to Treat C. difficile Infection Ling C.-C., Zhang P., Eugenio L., Ng K.K.
08:40 00333 Towards the Total Synthesis of Nucleotidylyltransferase Inhibitors as Antibiotics Loranger M.W., $Jakeman D.L.
09:00 00334 Characterization of E. coli PgaB, an Enzyme Essential for Biofilm Formation Poloczek J., Chibba A., Little D., Howell L., $Nitz M.
09:20 00335 Multifunctional Multivalency: The Synthesis of 2-Acetamido-2-deoxy-D-galactose Analogs of PK Trisaccharide for Selective Binding to Shiga Toxin Type 2 Jacobson J.M., *Kitov P.I., $Bundle D.R.
09:40 00336 Chemistry and Enzymology of 3,3'-Neotrehalosadiamine Synthesis *$Palmer D.R.J., Sanders D.A.R., Anjum S., Boisvert J., Langill D.L., van Straaten K.E., Vetter N.D., Rubin J.E.
10:00 Coffee Break
CCUCC Chemistry Doctoral Award Lecture

10:20 00337 Insight Into O-GlcNAc Protein Modifications Using Chemical and Biochemical Tools Macauley M.
11:00 00338 Progress in Total Synthesis of Tumor Associated Carbohydrate Antigen LeaLex Hexasaccharide Guillemineau M., *Auzanneau F.-I.
11:20 00339 Generation of Specific Substrates for Cellulases from Hypocrea Jecorina Rich J.R., Rasmussen T.S., Li K.-Y., Chen F., Withers S.G. WITHDRAWN
11:40 00340 Sialic Acid: Mammlian Cell Adhesion and Parasite Infection $Field R.A.
12:20 End of Session

BM13516c

Natural Product Chemistry (joint with OR4)

Organizer(s) - C. Spino
Chair(s) - Claude Spino

08:00 See OR4.

12:20 End of Session

BM12513e

Computational Biochemistry and Drug Design (joint with PT7)

Organizer(s) - G. Lamoureux; N. Moitessier
Chair(s) - Guillaume Lamoureux

08:00 See PT7.

12:20 End of Session

BM17516d

Solution NMR: Biomolecular Structure, Dynamics, and Function (joint with PT9)

Organizer(s) - A. Mittermaier; P. Lavigne
Chair(s) - Pierre Lavigne

08:00 See PT9.

12:20 End of Session

BM10510c

Anti-infective Medicinal Chemistry

Organizer(s) - C. Sturino; K. Auclair
Chair(s) - Claudio Sturino

08:15 Introductory Remarks

08:20 00341 Resistance to b-Lactam Antibiotics in Methicillin-Resistant Staphylococcus aureus (MRSA) *$Mobashery S.
09:00 00342 Prodrug Inhibitors of the Aminoglycoside Resistance-causing Enzyme AAC(6') from Enterococcus faecium Vong K., Tam I.S., $Auclair K.
09:20 00343 HIV-1 Integrase Inhibitors Wai J.
10:00 Coffee Break
10:20 00344 Discovery of BILB 1941, a Non-Nucleoside Polymerase Inhibitor for the Treatment of Hepatitis C Virus Infection *$Stammers T.A.
10:40 00345 Selective Inhibition of Trimethoprim-resistant, Type II R67 Dihydrofolate Reductase Bastien D., Kadnikova N., Forge D., Gauchot V., Vanden Eynde J.J., Schmitzer A.R., *$Pelletier J.N.
11:20 00346 Investigation into the Processing of Fluorinated Methionines by Trichomonas vaginalis Methionine Gamma-Lyase 1 Moya I.A., *$Honek J.F.
11:40 End of Session

BM9510a

Cancer Therapeutics  

Organizer(s) - J. Gillard; J. Jaquith
Chair(s) - John Gillard

08:00 00347 Discovery of IPI504/493 Adams J.
08:40 00348 From Novobiocin to Preclinical Lead Compounds that Target the Hsp90 C-Terminus for the Treatment of Cancer *Blagg B.S.J.
09:20 00349 HDAC Inhibitors Besterman J.
10:00 Coffee Break
10:20 00350 Topoisomerase Inhibitors Pommier Y.
11:00 00351 Discovery of Potent, Orally Bioavailable, and Brain-penetrant KSP Inhibitors Siddiqui A.
11:40 00352 Development of MK-4827: An Orally Active Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors Jones P., Altamura S., Boueres J., Ferrigno F., Fonsi M., Gavory G., Giomini C., Koch U., Lamartina S., Monteagudo E., Ontoria J.M., Roscilli G., Rowley M., Scarpelli R., Schultz-Fademrecht C., Toniatti C.
12:20 End of Session

BM1510b

Enzyme Structure-Function

Organizer(s) - J. Keillor
Chair(s) - Joanne Turnbull

08:00 00353 An Effort to Develop Novel Classes of Antimalarials *$Kotra L.P.
08:40 00354 Optimization of Pyruvate Kinase Inhibitors as Potential Therapeutics for the Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infections Kumar N.S., Moreau A., Labriere C., Zoraghi R., Gong H., See R.H., Finlay B.B., Worrall L., Strynadka N.C., Reiner N.E., $Young R.N.
09:00 00355 Parallel Synthesis of Highly Substituted 2-Aminopyridine Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS) Lin Y.S., $Tsantrizos Y.S.
Boehringer Ingelheim (Canada) Doctoral Research Award Lecture

09:20 00356 Some Enzymology Experiments on Ribozymes and DNAzymes Thomas J.M., *$Perrin D.M.
10:00 Coffee Break
10:20 00357 Cofactor Mobility Determines Reaction Outcome in the IMPDH/GMPR Family *$Hedstrom L.
11:00 00358 Investigating RebC-Mediated Chemoselective Oxidation during Rebeccamycin Biosynthesis Groom K.A., $Zechel D.L.
11:20 00359 Mechanistic Investigation of the Biodegradation of an Organophosphonate by PhnY and PhnZ McSorley F.R., Martinez A., DeLong E.F., *$Zechel D.L.
11:40 00360 A Role for Flexible Loops in Enzymatic Catalysis *$Richard J.P., Amyes T.L., Malabanan M.M.
12:20 End of Session

BM3516a

Radiopharmaceuticals and Imaging (joint with IN6)

Organizer(s) - R. Schirrmacher; P. Caravan
Chair(s) - Xiao-an Zhang; Tim Storr

08:00 00361 Recent Developments in 68Ga-labeling of Biomolecules for Application in PET Imaging *Wängler C., Schirrmacher R., Bartenstein P., Wängler B.
08:40 00362 Development of PET Radiopharmaceuticals for Probing the Serotonin System In Vivo Gillings N.
09:20 00363 Radioligands for the Estrogen Receptor van Lier J.E.
10:00 Coffee Break
10:20 00364 The Basic Chemistry and Logistics Behind Producing a Radiopharmaceutical for Human Use *$Lazarova N., Chio J., Valliant J., Simms R.
11:00 00365 Perspectives on Focal Tissue Hypoxia: Chemistry, Biochemistry and Imaging Wiebe L.I.
11:40 00366 Application of PET Imaging to Monitor Direct Enzyme Replacement Therapy *Phenix C.P., Rempel B.P., Colobong K., Doudet D.J., Adam M.J., Clarke L.A., $Withers S.G.
12:00 00367 Two-Step/One-Pot 18F-Radoplabeling of Oligonucleotides with Aryltrifluoroborates For PET Li Y., *$Perrin D.P.
12:20 End of Session

BM18511f

Supramolecular Materials

Organizer(s) - H. Sleiman; A. Schmitzer
Chair(s) - Andreea Schmitzer; Steve Loeb

08:00 Joint with MT and OR - see MT2.

12:20 End of Session


Wednesday PM

BM4516e

Advances in Spectroscopy and Imaging for Biological Systems (joint with PT4)

Organizer(s) - R. Campbell; G. Cosa
Chair(s) - Chris Cairo

13:40 See PT4.

17:40 End of Session

BM17516d

Solution NMR: Biomolecular Structure, Dynamics, and Function (joint with PT9)

Organizer(s) - A. Mittermaier; P. Lavigne
Chair(s) - Anthony Mittermaier

13:40 See PT9.

18:00 End of Session

BM10510c

Anti-infective Medicinal Chemistry

Organizer(s) - C. Sturino; K. Auclair
Chair(s) - Karine Auclair

13:40 00368 Discovery of BI 201335: A Potent and Specific Inhibitor of the Hepatitis C Virus NS3/4A Protease with Proven Antiviral Effect in Humans *Llinàs-Brunet M., Bailey M.D., Bhardwaj P.K., Bös M., Cordingley M.G., Duan J., Forgione P., Garneau M., Goudreau N., Kawaï S., Kukolj G., Lemke C., Poupart M.-A., White P.W.
14:20 00369 Synthesis and In Vitro Biological Activity of Novel Chloroquine and Mefloquine Ferrocenyl Carbohydrate Conjugates for the Treatment of Malaria Salas P., Herrmann C., Nimphius C., Kenkel A., Adam M.J., *$Orvig C.
14:40 00370 RNA-binding Natural Products: Exploiting Structure and Function Hanessian S.
15:20 00371 Fragment-Based Screening and Structure-Based Drug Design for IspF, an Infectious Disease Structural Genomics Drug Target *Begley D.W., Davies D.R., Hagen T., Zhang Z., Clare M.X., Hartley R.C., Burris C., Leonard J.T., Edwards T.E., Abendroth J., $Staker B.L., Myler P.J., Stewart L.J.
15:40 Coffee Break
16:00 00372 Chemical Genomics: Antibacterial Agents as Probes of Biological Complexity *$Brown E.
16:40 00373 Fusion of Known Antibiotics for Synergistic and Emergent Antimicrobial Activity Findlay B., Zhanel G.G., *Schweizer F.
17:00 End of Session

BM9510a

Cancer Therapeutics  

Organizer(s) - J. Gillard; J. Jaquith
Chair(s) - John Gillard

13:40 00374 Discovery and Development of Chk1 Inhibitors as Anti-Cancer Agents Barda D.A.
14:20 00375 Modulation of the JAK/STAT Pathway with a JAK-Selective Inhibitor Chrencik J., Emmons T., Hall T., Tomasselli A., Benson T., Knaffels J., Varghese A., Pandit J., Robinson R., Vazquez M., Fobian Y., Coe J.
15:00 00376 The Story of BP1-102: A Potent, Orally Available Stat3 Inhibitor for the Treatment of Human Cancers Page B.D.G., Fletcher S., Trudel S., Turkson J., Schimmer A.D., *$Gunning P.T.
15:40 Coffee Break
16:00 00377 Decorating Purine-based Stat3 Inhibitors with Drug-like Functionalities to Improve Cell Permeability and Anti-cancer Potency *Shahani V.M., Ball D.P., $Gunning P.T.
16:20 00378 Salicylic Based Inhibitors Targeting Transcriptionally Active STAT3 in Cancer Cells Haftchenary S., Page B., Schimmer A., $Gunning P.
16:40 00379 Structure-Based Inhibitor Design for Aberrant STAT5 Proteins in Leukemia Cumaraswamy A., $Gunning P.T.
17:00 00380 Selective SH2 Domain Proteomimetics as Potent Disruptors of SH2 Domain-Mediated Cell Signaling *Drewry J.A., $Gunning P.T., Duodu E.A.
17:20 00381 Artificially Inducing Protein Membrane Anchorage of Signal Transducer and Activator of Transcription 3 (Stat3) Protein via Membrane Associative Recognition Agents Avadisian M., *Fletcher S., Liu B., Zhao W., Yue P., Badali D., Xu W., Schimmer A.D., Turkson J., Gradinaru C.C., $Gunning P.T.
17:40 00382 Tubulin-Derived Peptides as Novel Ligands for RHAMM/HMMR Expressing Cancer Cells Esguerra K.V.N., Akentieva N., Ward C., Shepherd T.G., Turley E.A., *Luyt L.G.
18:00 End of Session

BM1510b

Enzyme Structure-Function

Organizer(s) - J. Keillor
Chair(s) - Andy Bennet

13:40 00383 A Potential Cope Rearrangement in the Reaction Catalyzed by Dimethylallyltryptophan Synthase Luk L.Y. P., Qian Q., *Tanner M.E.
14:20 00384 Cloning, Expression and Characterization of DcsC from Streptomyces lavendulae: A Racemase Involved in the Biosynthesis of D-Cycloserine Dietrich D., van Belkum M.J., *$Vederas J.C.
14:40 00385 Synthesis of Novel Fluorinated Derivatives of b-glucose-1-phosphate and their Enzymatic Evaluation in a Phosphoryl Transfer Reaction Bhattasali D., *$Jakeman D.L.
15:00 00386 Characterization of GlfT2, A Bifunctional Galactofuranosyltransferase Involved in the Biosynthesis of the Mycobacterial Cell Wall Poulin M.B., Wheatley R.W., Ng K.K.S., *Lowary T.L.
15:40 Coffee Break
16:00 00387 Investigating Allosteric Inhibition of Dihydrodipicolinate Synthase *$Palmer D.R.J., Skovpen Y.
16:40 00388 Allosteric Effects in the Unproductive Complex in the Antibiotic Resistance Causing Enzyme Aminoglycoside N-6'-Acetyl Transferase-Ii Freiburger L.A., Mittermaer A., Auclair K.
17:00 00389 Bioactivation of Nitroglycerin by Glyceraldehyde-3-phosphate Dehydrogenase to Clinically Relevant Products and Implications in Nitrate Tolerance Ouellet M., Seabra A.B., *$English A.M.
17:20 00390 Probing the Activity and Inhibition of TyrA Proteins: A (Two) Class Act $Turnbull J.L., Hotz N., Hassounah S., Quashie P.
18:00 End of Session

BM3516a

Radiopharmaceuticals and Imaging (joint with IN6)

Organizer(s) - R. Schirrmacher; P. Caravan
Chair(s) - Bjoern Waengler; Ralf Schirrmacher

13:40 00391 Recent Advances in the Coordination Chemistry of MR and Near IR Probes Meade T.J.
14:20 00392 New Fluorescent MMP2 Activable Probes based on Cy5/QSY21 and the Impact of their Impromptu Dimerization on their Absorption Spectra Lebel R., Bonin M.A., Zriba R., Radulska A., Neugebauer W., *$Lepage M.
15:00 00393 Using the Design of Nature's Own Nanoparticles as a Template to Create Multifunctional Probes Mulder W.J.M., Cormode D.P., Fayad Z.A.
15:40 Coffee Break
16:00 00394 New ParaCEST Agents by Ligand and Metal Variation: Searching for the Right Combination *$Hudson R.H.E.
16:40 00395 Direct Protein Imaging with MRI Alford J., Farrar C., Yang Y., Chronik B., Caravan P.
17:00 00396 Crosslinked Biocompatible Dendrimers as Increased Relaxivity MRI Contrast Agents Maris M. W.L., *Bondu F., $Gillies E.R.
17:20 00397 Indium-111-Labeled Block Copolymer Micelles for Imaging and Cancer Therapy Fonge H., Lee H., Hoang B., Reilly R., Allen C.
18:00 End of Session

BM18511f

Supramolecular Materials

Organizer(s) - H. Sleiman; A. Schmitzer
Chair(s) - Cornelia Bohne; James Wuest

13:40 Joint with MT and OR - see MT2.

18:00 End of Session

BM14511c

Metals in Enzymes (joint with IN7)

Organizer(s) - D.S. Bohle
Chair(s) - D. Scott Bohle

13:40 See IN7.

18:00 End of Session

BMpos517ab

Poster Session

From 17:40 until 20:30

Enzyme Structure-Function posters

17:40 02411 Study on the Effect of Lowering the Number of Rotational Degrees of Freedom in the Formation of Triple-Stranded Dinuclear Lanthanide Helicates Ryan P.E., Croset L., Guenee L., Piguet C.
17:40 00398 Phenylalanine Ammonia Lyase and Peroxidase: Structural and Functional Aspects *$D'Cunha G.B.
17:40 00399 Effect of Random Sequence Errors on Heterogeneity of E. colib-Galactosidase *$Craig D.B., Chase L.N., Schwab T., Sterner R.
17:40 00400 Modified Alginate and Chitosan Beads as Supports for Urease Immobilization *$Bahadur A.
17:40 00401 Probing Protein-Protein Interactions Between Karyopherin a2 and Influenza A Matrix 1 Protein Hang P.C., Franke W.A., Miknis Z.J., Umland T.C., *$Schultz L.W.

Enzyme Structure-Function - Graduate Student Poster Competition

17:40 00402 Investigation of a Homocystinuria-Association Mutations of Residues in the Active Site of Cystathionine b-Synthase Abouassaf E.A., *$Aitken S.M.
17:40 00403 Identification of the Acceptor Substrate Binding Site of Human Tissue Transglutaminase by Photolabeling Roy I., Smith O., Pardin C., *Keillor J. W.
17:40 00404 Design and Synthesis of Substituted Methyl Ketones as Inhibitors of Atg4B Nguyen T., $Young R.N.
17:40 00405 An Assessment of Native Tryptophan Residues as Probes of the Conformation and Stability of E. coli Cystathionine b-Lyase Jaworski A.F., *$Aitken S.M.
17:40 00406 Development of a Continuous Assay for Threonine Synthase Morneau D.J.K., $Aitken S.M.
17:40 00407 A Modified Futalosine Pathway for Menaquinone Biosynthesis in Campylobacter jejuni Li X., *Tanner M. E., Apel D., Gaynor E. C.
17:40 00408 Characterization of a Newly Uncovered Glycosyl Hydrolase Activity in Acetyl Xylan Esterase A from Streptomyces lividans Nguyen Thi N., Brault G., Dupont C., $Doucet N.
17:40 00409 Toward Elucidating the Transition-State Structure of AlkA (3-Methyladenine DNA Glycosylase II)-Catalyzed N-Glycoside Hydrolysis Azhikannickal V.J., $Berti P.J.
17:40 00410 Investigating the Role of Conserved Active-Site Residues in Cystathionine c-synthase Hopwood E.M.S, Lodha P.H., Manders A., Aitken S.M.
17:40 00411 Probing the Structure and Stability of Mono- and Bifunctional Forms of a Tyrosine Biosynthetic Enzyme from Haemophilus influenzae Kim H.Y., $Turnbull J.
17:40 00412 Solution Structure of Calmodulin Bound to Peptide from Inducible Nitric Oxide Synthase Piazza M., Dieckmann T., *$Guillemette J.G.

Peptide Science Posters

17:40 00413 Anti-Oxidant, Anti-Diabetic and Anti-Hyperextensive Effects of Extracted Phenolics and Hydrolized Peptides from Barley Protein Fractions *Alu'datt M.H., $Almajwal A.
17:40 00414 Isolation and Characterization of Protein Fractions From Black Cumin (Nigella sativa) Alu'datt M.
17:40 00415 Aza-aminosulfonamides as Amino Acid Surrogates for Application in Biologically Active Peptides Turcotte S., *Lubell W.D.
17:40 00416 Synthesis of Cyclic Tetrapeptide-based Imaging Probe Nsiama T.K., *Luyt L.G.
17:40 00417 Preparation and Structure-Activity Relationship Studies of Neopetrosiamide Analogues (Potent Anti-Metastatic Compounds) Chaytor J.L., Liu H., Towle K., $Vederas J.C.
17:40 00418 Novel Sulfahydantoin Constrained Peptides Lapointe Verreault C., Tremblay M., *Voyer N.
17:40 00419 Synthesis and Application of 2-Pyrrolylalanine to Explore the Influence of Aromatic Density on Prolyl Amide Isomer Population in Peptides Dörr A.A., *Lubell W.D.
17:40 00420 Poly(vinyl alcohol)-graft-poly(ethylene glycol) Resin Applications in Peptide Synthesis Kassem T., Sabatino D., Zelli R., Zhu X.X., *$William W.D.
17:40 00421 Progress Towards the Synthesis of N-Amino Hydantoin Peptide Mimics Garcia Ramos Y., *$Lubell W.B.

Peptide Science - Graduate Student Poster Competition

17:40 00422 A Simple and Efficient Approach to Prepare One-bead One-compound Cyclic Peptide Librairies for Ligands Identification *Girard A., $Biron E.
17:40 00423 Structural Changes of Model a-helical Transmembrane Segments in the Presence of Detergents Tulumello D.V., Alvares R.D., Macdonald P.M., Prosser R.S., Deber C.M.
17:40 00424 Structure-Activity Studies on a Model Antimicrobial Peptide Incorporating Cationic Amino Acids Paquet-Côté P.-A., Provencher M.-E., Cardinal S., Bédard L., Caron É., *Voyer N.
17:40 00425 Synthesis of Amino-Imazolidinone, Tetrahydropyrimidinone and Dihydrodiazapinone Peptidomimetics Hopewell R., *$Lubell W.D.
17:40 00426 Structure/Activity Relationship and Plasma Stability Studies of Apelin's Peptide Analogues $Murza A., Karadereye F., Tremblay H., Beaudet N., Sarret P., Marsault E.
17:40 00427 Synthesis of Novel NS2 Protease Inhibitors of the Hepatitis C Virus Hassanpour A., *Forgione P.
17:40 00428 An Investigation of Using Ionic Liquids for Selective Extraction of Phosphopeptides *Sanon S.H., Schmitzer A.R., Waldron K.C.
17:40 00429 NMR Solution Structures of Leucocin A Mutants Lohans C.T., Sit C.S., Campbell C.D., van Belkum M.J., *$Vederas J.C.

Radiopharmaceuticals and Imaging posters

17:40 00430 Copper-64 Labeling of Phthalocyanine-based Photosensitizers for Positron Emission Tomography (PET) Imaging $Ranyuk E.R., Cauchon N., Ali H., Guerin B., *van Lier J.E.
17:40 00431 Production Routes to the Radiotherapy Isotope 177Lu at McMaster Nuclear Reactor *$Armstrong A.F., Morim D.R., Alsop R.J.
17:40 00432 A Distillation-Based 99Mo/99mTc Generator using Low Specific Activity 99Mo? *$Armstrong A.F., Alsop R.J.
17:40 00433 Synthesis and Biological Evaluation of a Novel Epidermal Growth Factor Receptor Tyrosine Kinase (EGFR-TK) Inhibitor as a Potential PET Imaging Agent Kazock J.Y., Rao S., Williams C., Jean-Claude B.J., *$Mzengeza S.

Radiopharmaceuticals and Imaging - Graduate Student Poster Competition

17:40 00434 A Gd(III) Functionalized Polymer Nanogel: An MRI Contrast Agent with Enhanced Relaxivity Soleimani R., Martinez F.M., Bonduelle C.V., *Scholl T.J., $Gillies E.R.

Biopolymers and Other Biomaterials for Medical Applications posters

17:40 00435 Towards Delineating the Cellular Uptake of Three-Dimensional DNA Nanostructures Fakhoury J., McLaughlin C., $Sleiman H.
17:40 00436 Chemically Modified Branched RNAs: Probes for Investigating the Structure and Function of the Debranching Enzyme (DBR1) Katolik A.K., *$Damha M.J., Montemayor E., Hart J.
17:40 00437 Biological Responses to Highly Wettable Silicone Surfaces Khan M.F., Shao Y., Wang Y., Chen Y, $Brook M.A.
17:40 00438 Self-Immolative Polymers: New Designs and Synthetic Approaches Chen E.K.Y., DeWit M.A., Wong A., Torres C., $Gillies E.R.
17:40 00439 Synthesis of Radioimmunoconjugates Lu Y., Liu P., Weinrich D., Majonis D., Herrera I., Feng C., Niehoff A., Boyle A., Ngo Ndjock Mbong G., Reilly R., *Winnik M.
17:40 00440 Functional Metal Chelating Polymers Synthesized by Anionic Ring-opening Polymerization *Illy N., Majonis D., Herrera I., $Winnik M.A.
17:40 00441 Synthesis and Properties of Well-defined Cholic Acid-based Homopolymer and Copolymers Shao Y., *Zhu X.X.
17:40 00442 Polyacrylamide Backbone Polymers for the Delivery of Radio-Immunoconjugates to the Nucleus of Breast Cancer Cells Liu P., Lu Y., Boyle A., Weinrich D., Reilly R.M., *Winnik M.A.
17:40 00443 PEG-Caffeine Conjugate as a Polymeric Binder for Heavy Metal Detoxification *$Leblond J., Bertrand N., Bouvet C., Petitjean A., Leroux J.-C.
17:40 00444 Synthesis and Aggregation Properties of Dissymmetric Phytanyl-Gemini Surfactants for use as Improved DNA Transfection Vectors *$Wettig S.D., Wang H.
17:40 00445 Using Polyelectrolytes Containing Photoresponsive Azobenzene-Peptide Monomers to Contrast Cytophilic Cell Responses to Physical Parameters Goulet-Hanssens A., *$Barrett C.J.
17:40 00446 Antimicrobial Agents Rasool R., Nishat N.
17:40 00447 Synthesis and Electronic Structure Studies of Calcium Phosphate Coating on Various Titanium Surface Kim S.

Biopolymers and Other Biomaterials for Medical Applications - Graduate Student Poster Competition

17:40 00448 Stability Study of Self-assembled Polymeric Micelles in Serum Lu J., Owen S.C., *$Shoichet M.S.
17:40 00449 Lanthanide-Encoded Poly (Styrene-co-Methacrylic Acid) Microspheres: Synthesis and Metal Ion Release Study Liang Y., Abdelrahman A.I., Baranov V., *Winnik M.A.
17:40 00450 Functionalization and Characterization of ABO-Blood Antigen-Functionalized Fluorescent Silica Microparticles *$Slaney A.M., Wright V.A., Meloncelli P.J., Jeyakanthan M., Buriak J.M., Lowary T.L., West L.J.
17:40 00451 Determination of Self-diffusion Coefficient of Solutes in Calcium Alginate Hydrogel by Fluorescence Correlation Spectroscopy Golmohamadi M., *Wilkinson K.

Carbohydrates and Glycobiology posters

17:40 00452 An Effective Strategy for Constructing Libraries of C-Alkylated Iminosugars Goddard-Borger E.D., $Withers S.G.
17:40 00453 Glycomimetic and Multivalency: A Smart Combination Towards Promising Therapeutic Strategies Chabre Y.M., Shiao T.C., *Roy R.
17:40 00455 Novel Lipid A Mimetics: Synthesis & Biological Investigations Lewicky J.D., Ulanova M., Jiang Z.-H.
17:40 00456 An Optimal Dissolved Oxygen Concentration for Maximum Galactose Content in the Fc N-Linked Glycans of a Monoclonal Antibody Kunkel J.P., Jan D.C.H., Yan W.Y., *$Butler M., Jamieson J.C.
17:40 00457 Activity-Based Proteomics Profiling for Identification and Quantification of Trichoderma reesei Cellulases Chen C.F., Withers S.G.

Carbohydrates and Glycobiology - Graduate Student Poster Competition

17:40 00458 Glycosyl-Acridinones: Sensitive Fluorescent Active Site Titration Agents for Glycosidases Duo T., $Withers S.G.
17:40 00459 Azasugars as Ice Recrystallization Inhibitors Doshi M.P., *$Ben R.N.
17:40 00460 Synthesis of Fragments of Tumor Associated Carbohydrate Antigen LeaLex Hexasaccharide Guillemineau M., *Auzanneau F.-I.
17:40 00461 Structurally Diverse Disaccharide Analogs of Antifreeze Glycoproteins and their Ability to Inhibit Ice Recrystallization Balcerzak A., Ferreira S., *$Ben R.N.
17:40 00462 Analysis of Monbretin A Binding to Human Pancreatic Alpha-Amylase Zhang X., $Withers S.G.
17:40 00463 Probing the Activity of an Alpha-(1[4)-mannosyltransferase Involved in Methylmannose Polysaccharide Biosynthesis Xia L., Zheng R.B., *Lowary T.L.
17:40 00464 Magnesium Ion Enhances Lanthanum-Promoted Monobenzoylation of a Monosaccharide in Water Dhiman R., $Kluger R.

Altered Proteins, Design and Engineering posters

17:40 00465 Photo-Control of CREB DNA Binding Using Chemical and Genetically Encoded Photo-Switches Ali A.M., *$Woolley G.A.
17:40 00466 Structure-based Design of Circularly Permutated and Frame-shifted Photoactive Yellow Proteins Kumar A., Al-Abdul-Wahid S., *$Woolley G.A.
17:40 00467 Gallium Analogs of Hemozoin: Modelling Antimalarial Drug Action $Dodd E., *Bohle D.S.

Altered Proteins, Design and Engineering - Graduate Student Poster Competition

17:40 00468 Towards a-Helical Peptide Ion Channel Nanostructures as Prodrugs $Hartwick K., Veilleux J., Carron É., Otis F., Voyer N.
17:40 00469 Probing the Determinates for Substrate Specificity within Arogenate Dehydrogenase Rachel N., Beaudoin G., *$Turnbull J.
17:40 00470 Using FRET to Detect Protein-Small RNA Interactions: Engineering the Viral Suppressor Proteins of RNA Silencing, p19, as In Situ Imaging Tools Danielson D.C., Koukiekolo R., Cheng J., Jakubek Z., $Pezacki J.P.
17:40 00471 A 96-Well Plate Coupled Enzyme Assay for Screening Aminotransferase Mutant Libraries Walton C.J.W., Burugu S., Eason M., *$Chica R.A.
17:40 00472 Azobenzene Photo-switches for Cellular Applications Beharry A.A., Sadovski O., Wong L., Tropepe V., *$Woolley G.A.
17:40 00473 Orthogonal Site-specific Bioconjugation of P450 Enzymes and their Reductases Ménard A., Karam P., Cosa G., *$Auclair K.

Nucleic Acids posters

17:40 00474 Time-Dependent Motor Properties of Molecular Spiders Samii L., Zuckermann M.J., Blab G.A., $Linke H., *Forde N.
17:40 00475 Single Atom Modification Leads to Enhanced Nucleotide Self-Assembly: The Role of Cation Briding in Na2(5'-GSMP) Kwan I.C.M., Delley R.J., Hodgson D.R.W., $Wu G.
17:40 00476 Cpep and Cptp Chemistry in RNA Synthesis Li J., Tram K., *$Yan H.

Nucleic Acids - Graduate Student Poster Competition

17:40 00477 Towards the Development of a Cytochrome c Biosensor Lee J.A., Andrews D.W., *$Li Y.
17:40 00478 Secondary Oxidative Pathways for C-Linked C8-Deoxyguanosine Adducts Derived from Phenolic Carcinogens Witham A.A., *Manderville R.A.
17:40 00479 Entropy and Metal Ions in the Malachite Green Binding RNA Aptamer Da Costa J.B., $DIeckmann T.
17:40 00480 Development of a General Approach for Solid-Phase Synthesis of Oligonucleotides Bearing C8-Aryl-Guanine Adducts Sproviero M., Schlitt K.M., *Manderville R.A.
17:40 00481 Synthesis and Properties of Oligonucleotides Containing a PNA-Based Nucleoside Analog Dimer with a 1,4-Triazole Linkage Efthymiou T.C., *Huynh V., $Desaulniers J.P.
17:40 00482 The Use of Single-Stranded DNA for the Formation of Gold-Nanoparticle (AuNP) Nano-Structures and the Development of a Biosensing Platform Kanda P., *Ali M., Aguirre S., $Li Y.
17:40 00483 Characterization of a GTP-Binding DNA Aptamer Lin L., $Li Y.
17:40 00484 Identification of a Small Molecule from a Complex Mixture that Activates a Catalytic DNA Tram K., Ali M., Aguirre S., $Li Y.
17:40 00485 Selection of Aptamers Against Vesicular Stomatitis Virus Neutralizing Antibodies Muharemagic D., $Berezovski M., *Bell J.C.
17:40 00486 Aptamer Base: A Collaboratively Built Knowledge Base About Aptamers McKeague M., Cruz-Toledo J., *$Dumontier M., DeRosa M.C.
17:40 00487 Selection of Aptamers Against Oncolytic Viruses and Their Binding Evaluation by Nanoparticle Tracking Analysis Chechik A., $Berezovski M.
17:40 00488 Investigation of the Effectiveness of an Aptamer for Dopamine as a Therapeutic Agent in an In Vivo Model of Cognitive Deficits Associated with Schizophrenia McConnell E.M., Madularu D., Walsh R., Holahan M.R., *$DeRosa M.C.
17:40 00489 6-Phenylpyrrolocytosine, a Molecular Spy to Monitor siRNA Biodistribution Azizi F., Wahba A.S., Deleavey G.F., Hudson R.H.E., *$Damha M.J.
17:40 00490 Structure and Dynamics of West Nile Virus 5' and 3' Untranslated Regions Dahabieh M.S., *$O'Neill M.A.
17:40 00491 A Robust Electronic Switch Made of Duplex/Quadruplex DNA *Huang Y., $Sen, Ge B., Yu H.
17:40 00492 Progress Towards the Synthesis of an RNA-PNA Chimeric Oligonucleotide *Gong W., $Desaulniers J.P.
17:40 00493 A Facile Approach to Fluorescent PNA: Synthesis, Incorporation, and Functionalization of an Azide-Containing PNA Monomer St. Amant A.H., Hudson R.H.E.

Cancer Therapeutics posters

17:40 00494 Chemical Synthesis and Biological Results of 3-Substituted-androsterone Derivatives as Potent Inhibitors of 17b-Hydroxysteroid Dehydrogenase Type 3 *Maltais R., Fournier M.-A., $Poirier D.
17:40 00495 Progress Towards a Library of Cyclic Aza-peptide Integrin Receptor Ligands Spiegel J., $Lubell W.D., *Kessler H.

Cancer Therapeutics - Graduate Student Poster Competition

17:40 00496 Synthesis and Biological Activity of Estradiol Derivatives as Potential Non-estrogenic Inhibitors of 17b-Hydroxysteroid Dehydrogenase Type 1 Ouellet E., Ayan D., Poirier D.
17:40 00497 Porphyrin-Appended Prodigiosenes: Synthesis and Biological Evaluation Hawco C., $Thompson A.
17:40 00498 Elucidating the Mechanism of Organoarsenicals; Potent Anti-Cancer Drugs for the Treatment of Acute Promyelocytic Leukemia Gu Y., *$Bohle D.S., Garnier N.
17:40 00499 Targeting Uba1 Specificity Through Rationalized, Iterative Functionalization of an Adenosine-based Scaffold da Silva S.R., *Lukkarila J.L.L., $Gunning P.T.
17:40 00500 Synthesis of New Potent and Selective Peptidomimetic Inhibitors of Matriptase Colombo E., Chagnon F., Désilets A., Duchêne D., Najmanovich R., $Leduc R., Marsault E.
17:40 00501 Inhibitors of Signal Transducer and Activator of Transcription 5 Protein as Cancer Therapeutic Agents Page B.D.G., Khoury H., Fletcher S., Minden M., *$Gunning P.T.
17:40 00502 Design and Sythesis of Retinoic Acid Receptor Agonist and Histone Deacetylase Inhibitor Hybrid Molecules for Anti-cancer Therapy Xing S., Zhao B., Cotnoir-White D., Mader S., *$Gleason J.L.

Anti-infective Medicinal Chemistry posters

17:40 00503 Discovery of Specific Inhibitors Against R67 Dihydrofolate Reductase to Counter Bacterial Resistance to Trimethoprim Bastien D., Kadnikova N., Forge D., Vanden Eynde J., $Pelletier J.

Anti-infective Medicinal Chemistry - Graduate Student Poster Competition

17:40 00504 Synthesis and Biological Evaluation of Acyldepsipeptide Antibacterial Analogs Goodreid J.D., *Cossett M., $Batey R.A., Leung E., Houry W.A.

New Advances in Medicinal Chemistry posters

17:40 00505 Novel Inhibitors of P75 Receptor *Nedev H., $Saragovi U.
17:40 00506 Development of 2,4-Disubstituted Pyrimidine Ring Templates: Dual Cholinesterase and Amyloid-b Inhibitors *$Rao P.P.N., Mohamed T., Yeung C.K., Zhao X., Habib L.K., Yang J.
17:40 00507 Synthesis of Gem-Difluoro Bicyclics to Reduce Metabolism in our Muscarinic M1 Agonists Cheng Y.X., Santhakumar V., Beaumont M., Labrie P., Tomaszewski M.J.
17:40 00508 New Applications for Fragment Methodologies: Use of Fragment Assisted Screening to Guide HTS and Application to the Discovery of New High-Affinity PDE10 Inhibitors *$Albert J.S., Akerud T., Geschwindner S., Horsefeld R., Johansson P., Scott C., Spadola L., Tian G., Holmquist C.R., Forst J.
17:40 00509 Synthesis of a-amino-b-hydroxy-c-lactam for Constraining Peptide Serine and Threonine Residue Bernard-Gauthier V., St-Cyr D.J., Beauregard K., Jamieson A.G., $Lubell W.D.
17:40 00510 Development of Non-Beta-Blocking Carvedilol Analogues for Suppressing Cardiac Arrhythmias Smith C.D., Jiang D., Vembaiyan K., Chen S.R.W., *$Back T.G.
17:40 00511 Tetrazol Based Pro-drug Development Targeting Bone Growth and Bone Related Disease *Morshed M.M., Arns S., Gibe R., $Young R.N.
17:40 00512 Structure-Activity Relationships of 2'-Fluorinated Uridine Derivatives Targeting Orotidine-5'-monophosphate Decarboxylase *$Kotra L.P., Lewis M., Meza Avina M.E., Wei L., Crandall I.E., Poduch E., Paige C., Kain K.C., Pai E.F.
17:40 00513 Discovery of Kopakamal as a Potential Antimalarial Agent *$Kotra L.P., Crandall I., Kain K.C., Pai E.F., Lee P.I.

New Advances in Medicinal Chemistry - Graduate Student Poster Competition

17:40 00514 Structure-Activity Study of the Anti-IL-1R Peptide 101.10 Using a- and b-Amino-c-Lactams Beauregard K., Boutard N., Jamieson A.J., Turcotte S., Ronga L., Quiniou C., Chemtob S., *Lubell W.D.
17:40 00515 The Synthesis of a Novel Series of Effective SH2 Domain Inhibtors Duodu E., *Drewry J., $Gunning P.
17:40 00516 FFARs Mixed Agonists: Synthesis and Optimization Tremblay H., Trottier A., Chagnon F., Beauregard A., Leclerc P., Boulais P., Langlois M.-F., $Marsault E.
17:40 00517 Drugs for Potential Disease Modification and Symptom Alleviation in Alzheimer's Disease Telpoukhovskaia M.A., Rodríguez-Rodríguez C., Cawthray J., Page B.D.G., Scott L.E., *$Orvig C.
17:40 End of Session

UPC-B517ab

Undergraduate Student Poster Competition

From 17:40 until 20:30

17:40 00518 Development of Potent and Cell Permeable 2,6,9-tri-substituted Purine-based Small Molecule Inhibitors of Stat3 Ball D.P., *$Gunning P.T.
17:40 00519 Design and Synthesis of Biologically Active SH2 Domain Mimetics as Potential Anti-Cancer Therapeutics. Kraskouskaya D., *$Gunning P.T.
17:40 00520 Potent Ice Recrystallization Inhibition (IRI) Activity of Para-Substituted Aryl Monosaccharides and 1,1-Linked Disaccharides Mancini R.S., *Capicciotti C.J., $Ben R.N.
17:40 00521 Steps Towards Characterization of a Trifunctional Enzyme Involved in Aromatic Amino Acid Biosynthesis $Grigorov G., *Turnbull J.
17:40 00522 Pyrene-Containing Ferrocene-ATP Bioconjugates for Dual-channel Optoelectrochemical Protein Kinase Detection Freeman D., *Martic S., Rains M., $Kraatz H.B.
17:40 00523 Probing the Protein Kinase Activity: Hydrophilic versus Hydrophobic Ferrocene ATP Bioconjugates Rains M., *Martic S., Freeman D., $Kraatz H.B.
17:40 00524 Production of High Specific Activity Radiotherapy Isotopes 186Re and 188Re via the Szilard-Chalmers Effect Morim D.R., *$Armstrong A.F.
17:40 End of Session


Thursday AM

BM9510a

Cancer Therapeutics  

Organizer(s) - J. Gillard; J. Jaquith
Chair(s) - James Jaquith

08:00 00525 Development and Application of Mitochondria-penetrating Peptides to Drug Delivery *$Kelley S.O.K.
08:40 00526 Small Molecule Inhibitors of the Inhibitor of Apoptosis Proteins (IAPs) Gillard J.W., Boudreault A., Bureau P., Laurent A., Morris S., Jaquith J., Durkin J.P., Humphreys R.
09:20 00527 Small Molecule Antagonist of Bcl-2 Proteins for the Treatment of Cancer Shore G.
10:00 Coffee Break
10:20 00528 Epigenetics, DNA Methylation, and Chromatin Modifying Drugs *Szyf M.
11:00 00529 Design, Synthesis, and Testing of Novel Inhibitors of the EZH2 H3K27me3 Mark Daze K., $Hof F.
11:20 00530 Novel Antiestrogens as Potential Therapeutic Agents for Breast Cancer Treatment Mendoza-Sanchez R., Cotnoir-White D., Mader S., *$Gleason J.L.
11:40 00531 Human Farnesyl Pyrophosphate Synthase: New Opportunities for a Challenging Therapeutic Target *De Schutter J.W., $Tsantrizos Y.S.
12:00 00532 Synthesis and Anti-Cancer Evaluation of Several Analogues of the Tripyrrolic Natural Product Prodigiosin *$Thompson A.
12:20 00533 Probing the Mechanism of Action of Ruthenium(III) Anticancer Agents Using In Vitro EPR Webb M.I., $Walsby C.J.
BM1510b

Enzyme Structure-Function

Organizer(s) - J. Keillor
Chair(s) - David Palmer

08:00 00534 Transition State Analysis of the AroA Reaction: The Challenge of Protonating a Carbon Base Lou M., Burger S. K., Gilpin M. E., Gawuga V., Capretta A., *$Berti P. J.
08:20 00535 Structure-Function of the Glyoxalase Metalloenzymes *$Honek J.F.
09:00 00536 Investigating Mechanisms of Resistance to the Thiopeptide Antibiotic Thiostrepton Myers C.L., Harris J., *$Honek J.F.
09:20 00537 Flavin Semiquinone Stability and Evolution of Function in Photolyases and Cryptochromes Damiani M.J., Nostedt J.J., Trasolini R.P., *$O'Neill M.A.
10:00 Coffee Break
10:20 00538 Are Good Influenza Sialidase Inhibitors Transition State Analogs? *$Bennet A.J., Shidmoossavee F.S., Chan J.
11:00 00539 Activity-based Protein Profiling of Kinases to Identify their Role During Hepatitis C Replication McKay C.S., Blais D.R., Liu J., Zhou H., Figeys D., *$Pezacki J.P.
11:20 00540 An Enzymologist's Holiday: Mechanistic Analysis of Activation and Signaling in Growth Factor Receptor Systems Schlee S., Wright Jr., J.D., Atanasova M., Sazinsky S.L., Riera T.V., Whitty A.
11:40 00541 Nature's Manifold Mechanisms for Glycan Degradation Jongkees S., *$Withers S.G.
12:20 00542 Overcoming Rapid Suicide-Peroxide Inactivation of Chloroperoxidase: Kinetic Modeling of a Gel Entrapped Peroxide-Resistant Biocatalyst *$Nazari K., Mahmoudi A., Abedini M., Soltani S.
BM3516a

Radiopharmaceuticals and Imaging (joint with IN6)

Organizer(s) - R. Schirrmacher; P. Caravan
Chair(s) - Raman Chirakal; Ralf Schirrmacher; Peter Caravan

08:00 00543 Evaluation of Bifunctional Chelates for Radiopharmaceutical Development Ferreira C.L., Yapp D.T.T., Gill R., Bensimon C., Jurek P., Kiefer G.E.
08:40 00544 Radiochemistry Has Come of Age in Canada: A View Via Retrospectroscopy *$Ruth T.J.
09:20 00545 Radiolabelled Peptide to Improve Cancer Diagnosis by Positron Emission Tomography *$Guérin B.
10:00 Coffee Break
10:20 00546 New Perspectives Towards Ga-68 Labeled Radiopharmaceuticals Notni J., Šime?ek J., Wester H.J.
10:40 00547 A Novel Ghrelin Analogue for the Molecular Imaging of Prostate Cancer McFarland M.S., McTavish J., Chen L., Lewis J.D., Dhanvantari S., *$Luyt L.
11:00 00548 High Molecular Weight Hyperbranched Polyglycerols: The Proper Cardiac Imaging Nanoprobe! *Saatchi K., Gelder N., Pourghiasian M., Hundal N., Brooks D.E., Bénard F., Gershkovich P., Wasan K.M., $Hafeli U.O.
11:20 00549 Development of Bifunctional Gallium Complexes for Dual-Modal Imaging Chiang L., $Storr T.
11:40 00550 Synthesis of Macrocyclic b-Sheet Mimics as Molecular Imaging Probes Hickey J.L., Simpson E.J., *$Luyt L.G.
12:00 00551 Synthesis of 18F-labeled LLP2A for use in PET Imaging Walker D., Li Y., *$Perrin D.M.
12:20 End of Session

BM18511f

Supramolecular Materials

Organizer(s) - H. Sleiman; A. Schmitzer
Chair(s) - Hanadi Sleiman; Dipankar Sen

08:00 Joint with MT and OR - see MT2.

12:20 End of Session

BM14511c

Metals in Enzymes (joint with IN7)

Organizer(s) - D.S. Bohle
Chair(s) - D. Scott Bohle

08:00 See IN7.

12:00 End of Session

BM16512c

Mass Spectrometry: Applications in Proteomics, Metabolomics and Biomarkers (joint with AN4)

Organizer(s) - L. Sleno; P. Thibault
Chair(s) - Pierre Thibault; Lekha Sleno

08:00 See AN4.

12:20 End of Session

BM11510c

New Advances in Medicinal Chemistry

Organizer(s) - M. Tomaszewski
Chair(s) - Mirek Tomaszewski

08:00 00552 Molecular Design in Medicinal Inorganic Chemistry *$Orvig C.
08:40 00553 Beta-turn Conformations About Thr and Val Residues in the Anti-inflammatory Peptide Rytvela: A Stereochemical SAR Investigation Using Alpha-amino-beta-hydroxy-gamma-lactam Peptide Mimics St-Cyr D.J., Beauregard K., Bernard V., Jamieson A.G., *$Lubell W.D.
09:00 00554 Novel Bone-targeting Pro-drug Conjugates as Dual Action Therapies for Osteoporosis *$Young R.N., Arns S., Moreau A., Morshad M.
09:40 00555 Impact of Passive Permeability and Gut Efflux Transport on the Oral Bioavailability of Novel Series of Piperidine-based Renin Inhibitors in Rodents *$Lévesque J.F., Bleasby K., Chefson A., Chen A., Dubé D., Ducharme Y., Fournier P.A., Gagné S., Gallant M., Grimm E., Hafey M., Han Y., Houle R., Lacombe P., Laliberté S., MacDonald D., Mackay B., Papp R., Tschirret-Guth R.
10:00 Coffee Break
10:20 00556 Gewald-Type Synthesis and Structure-Activity Relationship Studies of Novel 2-Aminothiophene Derivatives as Isoprenoid Biosynthesis Inhibitors Langille A.M., *Tsantrizos Y.S.
10:40 00557 Development of Novel VR1 Antagonists for the Treatment of Pain Griffin A.M.
11:20 00558 Target Mutations Spurring Drug Design Mansour T.S.
12:00 00559 Modular Substituted Piperazine Synthesis. New Approaches for the Preparation of Calcium Ion Channel Blockers Borzenko A.O., *Snutch T.P., $Schafer L.L.
12:20 End of Session


Thursday PM

BM9510a

Cancer Therapeutics  

Organizer(s) - J. Gillard; J. Jaquith
Chair(s) - James Jaquith

14:40 00560 Cells in Gels in Paper: High-throughput Platform to Study Cell Function in 3D Tissues *Derda R., Ingber D.E., $Whitesides G.M.
15:00 00561 Encapsulation and Triggered Release of Hydrophilic Liquid Agents from Perfluorocarbon Droplets for Cancer Imaging and Therapy Gorelikov I.G., Seo M.S., Martin A.M., $Matsuura N.M. WITHDRAWN
15:20 00562 Exploring the Structural Determinants of NAE Specificity: Potent Inhibitor Design Leading to K562 Leukemia Cell Death Lukkarila J.L.L., *da Silva S.R., $Gunning P.T.
15:40 Coffee Break
16:00 00563 Azetidines to Pyrrolidines: A New Rearrangement *$Yadav V.K., Narhe B.D. WITHDRAWN
16:20 00564 To Image Breast Cancer with MMP Inhibitor 18F-Marimastat-Aryltrifluorborate Li Y., auf auf dem Keller U., Ting R., Bellace C.L., Harwig C., Lange P.F., Inkster J., Adam M.J., Schaffer P., Ruth T.J., Overall C.M., *$Perrin D.M.
16:40 00565 Micro-fluidic Technology: An Economical and Versatile Approach for the Synthesis of Clinical Radiotracers [18F]FET and [18F]FAZA Bouvet V.R., Tam P.H., *$Wuest F.
17:00 00566 Fluorescent Alpha-tocopherol Analogs as Tools in the Development of New Anti-cancer Agents Sveen C., *$Heyne B.
17:20 End of Session

BM3516a

Radiopharmaceuticals and Imaging (joint with IN6)

Organizer(s) - R. Schirrmacher; P. Caravan
Chair(s) - Neil Vasdev

14:40 00567 N-Succinimidyl 3-(di-tert-butyl[18F]fluorosilyl)benzoate ([18F]FSiB) a Novel Synthon for Protein Labeling *Kostikov A.P., $Schirrmacher R., Chin J.
15:00 00568 N-(4-(di-tert-butylfluorosilyl)benzyl)-2-mercapto-N,N-dimethylethanaminium bromide (SiFA+-SH Br-) - A Novel Cationic Thiol-functionalized Synthon of Reduced Lipophilicity for Peptide Labelling Chin J., Kostikov A., Lennox R.B., *$Schirrmacher R.
15:20 00569 Novel Strategy for the Synthesis of a Carbon-11 Labeled Glycogen Synthase Kinase-3b Inhibitor Hicks J.W., Wilson A.A., Houle S., *$Vasdev N.
15:40 Coffee Break
16:00 00570 Development of a Technetium (99mTc) Imaging Agent for Deep Vein Thrombosis Riddoch R.W., Dufour J.-M., Bump E.
16:40 00571 Radiometals at TRIUMF: A Collaborative Program to Demonstrate the Production of Tc-99m (and other metals) on an Existing Medical Cyclotron Infrastructure *$Schaffer P.
17:20 00572 Detection of Cancer Cells using Re/Tc Bioconjagates in Dual-Modal Imaging Huang R., Storr T., Yapp D., Gill R., Li C.
17:40 00573 Synthesis and Biological Distribution Studies on Radioiodinated Methylbenzylamines (ERC-9): A Potential Pancreatic Imaging Agent *$Sharma S.K., Joshua A.V., Abrams D.A., Scott J.R., Strelkov A., McEwan A.J.B.
18:00 End of Session

BM18511f

Supramolecular Materials

Organizer(s) - H. Sleiman; A. Schmitzer
Chair(s) - John Sherman; Normand Voyer

14:40 Joint with MT and OR - see MT2.

18:00 End of Session

BM11510c

New Advances in Medicinal Chemistry

Organizer(s) - M. Tomaszewski
Chair(s) - Mirek Tomaszewski

14:40 00574 P2X3 Antagonists for the Treatment of Pain *$Walpole C.
15:20 00575 Isoquinucline-based GlyT1 Inhibitors for Schizophrenia; Discovery, Optimization, Synthesis, and In Vivo Pharmacology *$Albert J.S., Alhambra C., Brugel T., Ernst G., Forst J., Jonak G., Koether G., Norris T., Potts W., Smaggin G., Sysderff S., Sylvester M., Tian G., Varnes J.G., Veale C.A., Wang X., Xiong H., Wood M.
15:40 Coffee Break
16:00 00576 EphA4 Kinase Inhibitors: A Novel Approach Toward Stroke Recovery *$Nantermet P.G., Moore K.P., Rajapakse H.A., Sanders J.M., Vacca J.P., Williams T.M., Zhu H., Finger E.N., Hess F.J., Krishnan R., Mark R.J., Regan C., Reynolds I.J., Abeywickrema P., Sharma S., Parmentier-Batteur S.
16:40 00577 Identification of a M1 Selective Agonist as Clinical Candidate from 1-Piperidin-4-yloctahydro-2H-benzimidazol-2-one Series *Santhakumar V., Cheng Y., Tomaszewski M., Coupal M., Jin S., Laird J., Luo X., Pousaraf M., Markoglou N.
17:00 00578 Utilization of an Alzheimer's Disease Hallmark for the Site-Specific Generation of Therapeutics Molecules Jones M.R., *Salehi A., $Storr T
17:20 00579 Novel Computational Tools for Drug Discovery and their Application to the Development of Prolyl Oligopeptidase Inhibitors *$Moitessier N., De Cesco S., Rocheleau S., Arreola-Barroso R., Juillerat-Jeanneret L., Therrien E., Levan D.
18:00 End of Session


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